Inositol and phosphoinositides

metabolism and regulation

Publisher: Humana Press in Clifton, NJ

Written in English
Cover of: Inositol and phosphoinositides |
Published: Pages: 698 Downloads: 24
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Subjects:

  • Inositol -- Metabolism -- Congresses.,
  • Phosphoinositides -- Metabolism -- Congresses.,
  • Inositol -- metabolism -- congresses.,
  • Phosphoinositides -- metabolism -- congresses.

Edition Notes

Statementedited by John E. Bleasdale, Joseph Eichberg and George Hauser.
SeriesExperimental biology and medicine, Experimental biology and medicine (Clifton, N.J.)
ContributionsBleasdale, John E., Eichberg, Joseph, 1935-, Hauser, George., Chilton Conference on Inositol and Phosphoinositides (1984 : Southwestern Medical School)
Classifications
LC ClassificationsQP772.I5 I56 1985
The Physical Object
Paginationxxii, 698 p. :
Number of Pages698
ID Numbers
Open LibraryOL3020005M
ISBN 100896030741
LC Control Number85000131

Haldar and Bhattacharjee and collaborators Robert Stahelin at the Indiana University School of Medicine- South Bend (who also is an adjunct faculty member in Notre Dame's Department of Chemistry and Biochemistry), and David and Kaye Speicher at the University of Pennsylvania's Wistar Institute discovered that for host-targeted malaria proteins the very first step is binding to the lipid. Different phosphoinositides enriched at the membranes of specific subcellular compartments within plant cells contribute to organelle identity, ensuring appropriate cellular trafficking and function. During the infection of plant cells, biotrophic pathogens such as powdery mildews enter plant cells and differentiate into haustoria. Each haustorium is enveloped by an extrahaustorial membrane. Inositol: | | |myo|-Inositol|[1]| | | | ||| | | World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most.   Phosphoinositides were?rst isolated from brain in by Folch and their structure was established in by Ballou and his coworkers. After the compilation of scattered publications on cyclitols by Posternak (), proceedings of the conference on cyclitols and phosphoinositides under the supervision of Hoffmann-Ostenhof, were p- lished in.

Phosphoinositides are minority phospholipids of all eukaryotic cellular membranes. Like other phospholipids they have a glycerol backbone esterified to two fatty acid chains and a phosphate, and attached to a polar head group that extends into the cytoplasm (Fig. 1A). For phosphoinositides, the head group is the cyclic polyol myo-inositol Cited by: @article{osti_, title = {Legionella phosphatase hydrolyzes phosphatidylinositol 4,5-bisphosphate and inosital triphosphate in human neutrophils}, author = {Dowling, J N and Saha, A K and Glew, R H}, abstractNote = {Legionella are facultative intracellular bacterial pathogens which multiply in host phagocytes. L. micdadei cells contain an acid phosphatase (ACP) that blocks superoxide. The term “conditionally essential” has been used to describe the role of choline, inositol, taurine, arginine, glutamine, and nucleotides in human nutrition. The biochemical pathways to synthesize these nutrients are present, and their absence from the diet does not lead to a classical clinical deficiency syndrome. Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more.

Many inositol compounds are found naturally in the human body, often in the form of phosphoinositides, and play roles in a great variety of molecular signaling pathways involved with cell proliferation and apoptosis, metabolism, movement of vesicles in the cell, fertility, and numerous other cellular functions. 2 In the human body, specific. Myo-inositol, or simply inositol, is a carbocyclic sugar that is abundant in brain and other mammalian tissues, mediates cell signal transduction in response to a variety of hormones, neurotransmitters and growth factors and participates in osmoregulation It is a sugar alcohol with half the sweetness of sucrose (table sugar). It is made naturally in human beings from glucose. Each kidney makes. Purchase Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases, Volume 30 - 1st Edition. Print Book & E-Book. ISBN ,

Inositol and phosphoinositides Download PDF EPUB FB2

The Chilton Conference on Inositol and Phosphoinositides, held on Januaryat Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides.

The first took place in in New York [Ann. Cyclitols and Phosphoinositides covers the proceedings of the Conference on Cyclitols and Phosphoinositides, held at the Kellogg Center for Continuing Education, Michigan State University, East Lansing, Michigan.

This book is organized into eight parts encompassing 43 chapters. Inositol, or more precisely myo-inositol, is a carbocyclic sugar that is abundant in brain and other mammalian tissues, mediates cell signal transduction in response to a variety of hormones, neurotransmitters and growth factors and participates in osmoregulation.

It is a sugar alcohol with half the sweetness of sucrose (table sugar). It is made naturally in humans from al formula: C₆H₁₂O₆.

Phosphoinositides. Phosphorylated forms of phosphatidylinositol (PI) are called phosphoinositides and play important roles in lipid signaling, cell signaling and membrane trafficking.

The inositol ring can be phosphorylated by a variety of kinases on the three, four and five hydroxyl groups in seven different combinations. However, the two and Chemical formula: C₄₇H₈₃O₁₃P.

Open Library is an open, editable library catalog, building towards a Inositol and phosphoinositides book page for every book ever published.

Inositol and phosphoinositides by John E. Bleasdale, Joseph Eichberg, George Hause,Springer edition, paperback. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward.

With the current genomic and proteomic tools in place the new role of inositols, inositol phosphates and phosphoinositides in cell signaling or stress Format: Hardcover. Buy Phosphoinositides and Disease (Current Topics in Microbiology and Immunology Book ): Read Kindle Store Reviews - ce: $ Biosynthesis: Phosphatidylinositol per se is the ultimate precursor of all phosphoinositides, the head groups of which have different charges and structures that impact directly on membrane properties and via metabolic interactions can function as chemical switches.

The individual phosphoinositides are maintained at steady state levels in membranes by a continuous and sequential series of. From being to becoming important, myo-inositol and its derivatives including phosphoinositides and phosphoinositols involved in diversi?ed functions in wide varieties of cells overcoming its insigni?cant role had to wait more than a century.

Myo-inositol, infact, is the oldest known inositol and it was isolated from muscle as early as and phytin (Inositol hexakis phosphate) from Inositol and phosphoinositides book by.

Phosphatidylinositol. Phosphoinositides (PIs) are phospholipids comprising a water-soluble head group (myo-inositol) linked by a glycerol moiety to two fatty acid chains, usually a saturated C18 residue (stearoyl) in the 1-position and a tetra-unsaturated C20 residue.

ISBN: OCLC Number: Notes: "The Chilton Conference on Inositol and Phosphoinositides, held on Januaryat Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides"--Preface.

phosphoinositides and phosphoinositols involved in diversified functions in wide varieties of cells overcoming its insignificant role had to wait more than a century. Myo-inositol, infact, is the oldest known inositol and it was isolated from muscle as early as and phytin (Inositol hexakis phosphate) from plants by Pfeffer in Book Annex Membership Educators Gift Cards Stores & Events Help.

Auto Suggestions are available once you type at least 3 letters. Use up arrow (for mozilla firefox browser alt+up arrow) and down arrow (for mozilla firefox browser alt+down arrow) to review and enter to : $ ISBN: OCLC Number: Description: xii, pages: illustrations: Contents: Chapter 1.

Structure and nomenclature of inositol phosphates, phosphoinositides, and glycosylphospatidylinositols / Pushpalatha P.N. Murthy --Chapter ol and plant cell wall polysaccharide biogenesis / Frank A. Loewus --Chapter 3. Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions.

This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases.

Dean NM, Moyer JD. Separation of multiple isomers of inositol phosphates formed in GH3 cells. Biochem J. Mar 1; (2)– [PMC free article] Drobak BK. Plant Phosphoinositides and Intracellular Signaling.

Plant Physiol. Jul; (3)– [PMC free article]Cited by: Vitamin B 8 (Inositol, cyclohexanehexol) is a sugar alcohol and isomer of glucose. As a nootropic, inositol is involved in brain cell signaling, and is a component of cell membranes.

Vitamin B 8 is no longer considered a ‘true’ B-Vitamin because your body can make inositol on its own. A “true vitamin” is either essential for life and/or cannot be made by the human body.

Biology of Inositols and Phosphoinositides. Editors: Lahiri Majumder, A., Biswas, B. B Structure and Nomenclature of Inositol Phosphates, Phosphoinositides, and Glycosylphosphatidylinositols.

Pages *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis. ebook access is temporary and. Cyclitols and Phosphoinositides covers the proceedings of the Conference on Cyclitols and Phosphoinositides, held at the Kellogg Center for Continuing Education, Michigan State University, East Lansing, Michigan.

This book is organized into eight parts encompassing 43 Edition: 1. Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions.

This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human : Springer Netherlands.

Identification of Phosphoinositides and Their Metabolic Fate. The real beginning of the “modern” era of PI research was marked by a series of ground-breaking studies in the s by Jordi Folch who identified inositol in the ethanol-insoluble phospholipid fraction of bovine brain and determined that it contained phosphates and inositol in a molar ratio of ().Cited by: This volume summarizes current research on cellular signal transduction involving inositol phosphates and phospholipids and features contributions from some of the leading laboratories.

Phosphoinositides - Karol S. Bruzik - Oxford University Press. Selected Reviews: Balla T () Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol. Rev. 93(3), – Hammond GR, Balla T () Polyphosphoinositide binding domains: Key to inositol lipid biology.

Biochim. Biophys. Acta (6), –; Lystad AH, Simonsen A () Phosphoinositide-binding proteins in autophagy. FEBS Lett. (15), – Phosphoinositides and Disease (Current Topics in Microbiology and Immunology Book ) (English Edition) eBook: Falasca, Marco: : Tienda KindleFormat: Kindle.

The availability of inositol may control the formation of surfactant phospholipids, including dipalmitoyl lecithin (phosphatidylcholine) and inositol phospholipid, in immature lung ol Cited by: Structure-Activity Relationships of Adenophostin A and Related Molecules at the 1-D-myo-Inositol 1,4,5-Trisphosphate Receptor Barry V.

Potter Chap DOI: /bkch Publication Date (Print): Decem   Inositol phospholipids are concentrated at the cytosolic surface of membranes. PtdIns, the precursor of phosphoinositides, is synthesized primarily in the endoplasmic reticulum (ER) and is then. Inositol Phosphates and Phosphoinositides in Health and Disease Article Literature Review in Sub-cellular biochemistry February with 35 Reads How we measure 'reads'.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and : Springer Netherlands.

A novel isomer of phosphatidylinositol that differs in the structure of the head group was detected in barley (Hordeum vulgare cv Himalaya) seeds. In this paper we describe our efforts to elucidate the structure of the novel isomer.

Evidence from a variety of techniques, including chemical modification of in vivo 32Pi- and myo-[3H]inositol-labeled compounds, gas chromatography-mass Cited by:.

A number of these sugar-alcohol isomers are biologically active, of which myo-inositol (MI) is the most common (Majumdar et al., ). It constitutes a component of membrane phospholipids and.

Buy Inositol and Phosphoinositides by John E. Bleasdale, Joseph Eichberg from Waterstones today! Click and Collect from your local Waterstones Book Edition: Ed.inositol phospholipids are collectively referred to as phosphoinositides (PIs).

In animal cells, PIs and their derivatives operate in signal transduction pathways triggered by stimuli as diverse as growth factors, hormones, neurotransmitters, and light (Berridge, ). Historically, the first major insight into the impor-Cited by: